PanaBIOS is built by African technologists and AI thinkers to provide biosurveillance and bioscreening technology, data, and insights to enable the creation of Public Health Corridors within the broader AU Open Corridors Initiative. It supplies the nuts and bolts of constructing a truly pan-African post-pandemic reopening architecture. PanaBIOS runs on BioCordon, an R&D output developed by African technologists with support from Harvard University’s Center for Public Leadership. A pan-African reopening strategy aligned with public health objectives presupposes an extensive system of public health surveillance, verifiable record-keeping, and data analysis to detect, track, and contain new infection cases as commerce and travel resume towards pre-crisis levels.